each case, must be in writing and shall be effective only to the extent specifically set forth in such writing. Agreement. You can also sign up for email updates on the SEC open data program, including best practices that make it more efficient to download data, and SEC.gov enhancements that may impact scripted downloading processes. expressly agree that the provisions of this Agreement may be specifically enforced against each of the parties hereto in any court of competent jurisdiction. Note: Regulatory filings since the quarter ended show them owning 4.7M shares (15.1% of business) of Entrada Therapeutics (TRDA). It is a very long-term stake that has been in the portfolio for over fifteen years. Q2 & Q4 2020 saw a two-thirds stake increase at prices between ~$12.50 and ~$57.50. Baker Brothers Life Sciences LP; Firm: Fund # CIK # 0001363364: Sale: Fund: Phone: 2123395633: Address: 667 Madison Avenue New York, New York 10065: Source The Ascendis stake was increased this quarter while decreasing Amarin and dropping Apellis Pharma. The funds philosophy stands in holding its investments ordinarily for three years, though its higher-conviction investments can be seen held for longer. benefit of, and be binding upon, the successors, assigns, heirs, executors, and administrators of the parties hereto. Disclosure: I/we have a beneficial long position in the shares of ACAD, BMRN, INCY either through stock ownership, options, or other derivatives. The position is now at 1.23% of the portfolio. 2023 PitchBook. This is compared to ~32M shares in the 13F report. Baker Bros Advisors was founded in 2000 and is based in New York City. This cookie is set by GDPR Cookie Consent plugin. (k)Jurisdiction. Prior to joining Baker Brothers in 2005, Mr. Goller was an associate of JPMorgan Partners, LLC where he focused on [] These cookies ensure basic functionalities and security features of the website, anonymously. They had an IPO in November. Although there are ~120 positions in the 13F portfolio, the holdings are concentrated among a few large stakes. 151.252.56.27 Recession Risk Determine whether Baker Brothers Life Sciences grew or shrank during the last recession. Angel, Fund of Funds, Venture Capital), This describes the stage of investments made by this organization (e.g. Companys Amended and Restated Certificate of Incorporation as in effect on the date hereof). To ensure this doesnt happen in the future, please enable Javascript and cookies in your browser. Baker Brothers Life Sciences, L.P. is a hedge fund operated by Baker Brothers Investments and has approximately $13.9 billion in assets. Pharmaceutical, a company in which the Baker Brothers Entities have been investor s since March 2006. Nominating Agreement as of the date first above written. Amarin Corp plc (AMRN): The original AMRN stake was built in Q3 2016 at prices between ~$2.15 and ~$3.15. Council Members. The original stake goes back to funding rounds prior to its Q4 2018 IPO. (g)Delays or Omissions. Retail investors should be wary of just copying the funds portfolio. There was a marginal increase this quarter. For security purposes, and to ensure that the public service remains available to users, this government computer system employs programs to monitor network traffic to identify unauthorized attempts to upload or change information or to otherwise cause damage, including attempts to deny service to users. Get the full list, Youre viewing 5 of 45 funds. Despite the uncertainty surrounding BeiGene, the company has developed into a fully integrated global biotechnology company with operations in China, the United States, Europe, and Australia. Please disable your ad-blocker and refresh. Baker Brothers Life Sciences, L.P. is a hedge fund operated by Baker Brothers Investments and has approximately $13.9 billion in assets. Please. I wrote this article myself, and it expresses my own opinions. breach or default, or an acquiescence therein, or of or in any similar breach or default thereunder occurring; nor shall any waiver of any single breach or default be deemed a waiver of any other breach or default therefore or thereafter occurring. There was a marginal increase in Q1 2021. Please send any feedback, corrections, or questions to support@suredividend.com. recommended to the Companys stockholders for election as directors of the Company at each annual or special meeting of the Companys stockholders at which directors are to be elected (an Election Meeting),one The Company shall notify the Investor of any objection to an Investor Designee pursuant to this Section2(b) sufficiently in advance of the date THIS AMENDED AND RESTATED NOMINATING AGREEMENT (this Agreement), dated as of April22, 2021, by and among TScan The position has remained almost steady since. email address below and choose 'Submit'. Felix Baker '91, PhD '98. Its flagship products include JAKAFI, which is a drug for the treatment of myelofibrosis and polycythemia, and Iclusig, a kinase inhibitor to treat chronic myeloid leukemia. Contact Info baker brothers life sciences lp 860 WASHINGTON STREET NEW YORK NY 10014 Business Phone: 212-339-5600 SEC SIC CODE: 8731-SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH Insider Information Trimeris Inc - Other Owner (06/22/2015) Xoma Corporation - Other Owner (07/22/2015) Genomic Health Inc - Director (10/01/2019) These investors may include private investors, venture capital firms, or other investment vehicles. PitchBook can help you gauge a funds performance based on IRR, cash flow multiples (DPI, RVPI and TVPI), distributions and more. Note: Baker Brothers controls ~6% of the business. address or email address (and with such copies, which shall not constitute notice) as identified below. Agreement); WHEREAS, the Company and the Investor desire to amend and restate the Original Agreement pursuant to the terms and Any waiver, permit, consent or approval of any kind or character on the part of the Investor of any breach or default of the Company under this Agreement, or any waiver on the part of any party of any provisions or conditions of this Agreement, in Focused on cloning strategies by analyzing 13F reports of a curated set of around fifty super-investors and generating Absolute Returns thru exploiting inefficiency, volatility, and momentum. Over the years, the firm had a number of home runs as the invested firms got acquired at huge premiums. Julian Baker and Felix Baker 's Baker Bros. Advisors recently filed an amended Form 13D with the SEC to report the sale of common shares of Biocryst Pharmaceuticals Inc (NASDAQ: BCRX). Since then, the activity has been minor. While the company has continued to grow, the business seems incapable of meeting investors past expectations. Note: We do not offer technical support for developing or debugging scripted downloading processes. The parties There are 20 positions that are significantly large (more than 0.5% of the portfolio each) and they are the focus of this article. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. This Agreement may be executed in any number of counterparts (including by facsimile or The top three positions are Seagen, BeiGene, and Incyte Corporation and they add up to almost ~64% of the portfolio. If you have an ad-blocker enabled you may be blocked from proceeding. San Francisco Bay Area, Silicon Valley), Operating Status of Organization e.g. Incyte Corporation (INCY): INCY was already a 1.67M share stake in their first 13F filing in Q2 2003. Updated on November 23rd, 2022 by Nikolaos Sismanis. 12b-2 under the Securities Exchange Act of 1934, as amended. Last major activity in MDGL was a ~30% stake increase in Q1 2020 at prices between ~$65 and ~$90. reserves the right to withhold any information and to exclude the Observer from any meeting or portion thereof that the (A)Board of Directors determines based upon the advice of outside counsel that (i)access to such information or substantially the same time and in the same manner as provided to such directors; provided, however, that such Observer shall agree to hold in confidence all information so provided; and provided, further, that the Company argenx SE (ARGX): The ARGX stake was primarily built in Q4 2017 at prices between ~$22.50 and ~$63. BeiGene Limited (BGNE): The large (top three) 18.60% BGNE stake has been in the portfolio since their US listing in Q1 2016. A privately owned hedge fund sponsor. However, the industry is full of risks, and when the companys patents expire, competition is likely to rise. Si vous y consentez, nous et nos partenaires utiliserons galement des cookies et autres traceurs de mesure daudience, de publicit et de rseaux sociaux, dont le dtail des finalits est accessible depuis le bouton Grer les paramtres . This is a profile preview from the PitchBook Platform. Although there are ~120 positions in the 13F portfolio, the holdings are concentrated among a few large stakes. Almost all of its funds are allocated to publicly traded equities, with exclusive exposure to the healthcare sector. Phone: 212-339-5600. otherwise and the term Common Stock shall include all such other securities. exercise any right, power or remedy accruing to the Investor hereto upon any breach or default of the Company under this Agreement, shall impair any such right, power or remedy of the Investor nor shall it be construed to be a waiver of any such Ascendis Pharma A/S (ASND): The bulk of the current ~3% of the portfolio stake in ASND was built in 2017 at prices between ~$20 and ~$40. However, the funds investing philosophy does hold up, as the top 10 holdings account for 86.4% of the total capital invested, confirming their inclination towards high-conviction investments. BeiGene is an early commercial-stage biopharmaceutical firm working on developing and commercializing innovative molecularly-targeted and immune-oncology drugs for the treatment of cancer. The rest of the stakes are very small. Additionally, Baker Bros. dont intend to dilute their status as highly successful biotech investors, as they do not intend to ever allocate assets in other industries. the slate of nominees recommended to the Companys stockholders for election as directors of the Company an Investor Designee if the Investor already has at least one Investor Designee serving as a director on the Board of Directors at the time BioMarin Pharmaceutical (BMRN): A small stake in BMRN was first purchased in 2006 but was eliminated the following year at higher prices. As a percentage of AUM, allocation to the highest conviction picks can be very high at over 30%. BioMarin Pharmaceutical formulates and markets therapies for people with severe and life-threatening rare diseases and medical ailments. Its stake in Seattle Genetics is up $1 billion since news of. They have a ~29% ownership stake in the business. Kath Lavidge '74, P '09 - Chair. Apellis Pharma (APLS): The small 0.63% APLS stake saw a ~36% increase last quarter at prices between ~$41 and ~$65. ACADIA Pharmaceuticals focuses on the development and commercialization of small molecule drugs aimed at unmet medical needs in central nervous system disorders. Youre viewing 5 of 7 investments. (a)Governing Law. Revenues have expanded from around $169 million in 2010 to $3.33 billion over the past four quarters. Total number of diversity investments made by an investor, Total number of employee profiles an organization has on Crunchbase, Total number of organizations similar to the given organization, Where the organization is headquartered (e.g. NOW, THEREFORE, for good and valuable consideration, the receipt and adequacy of which are The current minimum investment for Baker Brothers Life Sciences, L.P. is $40000000. This information is available in the PitchBook Platform. Is this happening to you frequently? The stock currently trades at ~$133. The funds strategy includes utilizing a fundamentally-driven way of investing to come up with its investment decisions, also known as bottom-up investing. Unauthorized attempts to upload information and/or change information on any portion of this site are strictly prohibited and are subject to prosecution under the Computer Fraud and Abuse Act of 1986 and the National Information Infrastructure Protection Act of 1996 (see Title 18 U.S.C. Farah Champsi MBA '85. This SEC practice is designed to limit excessive automated searches on SEC.gov and is not intended or expected to impact individuals browsing the SEC.gov website. Recent M&A winners include Pharmacyclics (acquired by AbbVie), Synageva (acquired by Alexion), Salix (acquired by Valeant), and Alexion (acquired by AstraZeneca). from time to time. validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. To explore Baker Brothers Life Sciencess full profile, request access. Baker Bros. Advisors LP 860 Washington Street, 3 rd Floor New York, NY 10014 (212) 339-5690 (Name, address and telephone number of person authorized to receive notices and communications) October 11, 2019 (Date of event which requires filing of this statement) Unlike top-down investing, which suggests studying the bigger picture of economic factors to make investment decisions, bottom-up investing involves looking at the company-specific fundamentals. The 2007-2008 timeframe saw the position increased from ~3.2M shares to ~11.1M shares at prices in the high single digits. This quarter saw a ~28% stake increase at prices between ~$113 and ~$177. All rights reserved. There was a ~35% reduction last quarter at prices between ~$26 and ~$40.50. under clause (c)or (d); (c) by prepaid certified or registered mail, return receipt requested;or (d)by prepaid reputable overnight delivery service. I have no business relationship with any company whose stock is mentioned in this article. Last significant activity was in Q4 2019 which saw a ~20% stake increase at prices between ~$14.50 and ~$76. of such counsel, that such person would not be qualified to serve as a director of the Company under any applicable law (including requirements of fiduciary duties under applicable law), rule or regulation, rule of the stock exchange on which the The bottom line has never been positive, however, with losses persisting even as sales are growing. This quarter also saw a minor ~4% trimming. For comparison, the S&P 500 ETF (SPY) generated annualized total returns of 10.2% over the same time period. Company and the Investor and (y)agreeing to be bound by the Companys insider trading and window policies then in effect and applicable to members of the Board of Directors. This website is using a security service to protect itself from online attacks. Baker Brothers, a biotech investment firm, was founded by Julian & Felix Baker in 2000. The parties hereto irrevocably submit, in any legal action or proceeding relating to For the Baker Bros. -- the biggest shareholder in both companies -- the value of its investments have soared by about $1.4 billion. Custodian(s): Continental Stock Transfer & Trust Company, . Please visit our, series to get an idea of their investment philosophy and our previous. Additionally, 100% of the funds holdings comprise companies operating in the healthcare sector. Mr. Goller began his career as an investment banker with Merrill Lynch and Co. from 1997 to 1999. Management owns 12 percent of the fund. The stock is now at $87.22, and the stake is at 2.59% of the portfolio. They add up to ~73% of the portfolio. or to simply have an email sent to you whenever we receive a new The parties expressly agree that the provisions of this Agreement may be (c)Bylaws means the Bylaws of the Company, as may be amended, restated or otherwise modified Sign-up (c)Subject at all times to Section3(n) below and the other limitations set forth in this Julian has a business background from Harvard, while Felix has a Ph.D. in Immunology from Stanford. High at over 30 % above written funds strategy includes utilizing a fundamentally-driven way of investing to come with. Stake in the business seems incapable of meeting investors past expectations in central nervous disorders. Allocation to the highest conviction picks can be seen held for longer conviction picks can be high... 2020 at prices between ~ $ 14.50 and ~ $ 40.50 the Baker Brothers Sciences... Grew or shrank during the last Recession have a ~29 % ownership stake in Seattle Genetics up. 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