Sabry, A. View abstract. Biochem Pharmacol 2003;65:1483-8.. View abstract. Zhongguo Wei Zhong.Bing.Ji.Jiu.Yi Xue 2011;23(12):739-742. J Dermatol.Sci 2007;48(2):141-144. Adv Exp Med Biol 1990;272:197-208. Even though the body produces it naturally, carnitine is widely available in a number of simple foods. Most people tolerate L-carnitine well. A., and Morrow, G. R. Pharmacologic treatment of cancer-related fatigue. WebFind wholesale l carnitine manufacturers from China, India, Korea, and so on. Acta Europ Fertil 1992;23:221-4. BJU.Int. Andreozzi, G. M., Leone, A., Laudani, R., Martin, R., Deinit, G., and Cataldi, V. Levo-propionyl-carnitine improves the effectiveness of supervised physical training on the absolute claudication distance in patients with intermittent claudication. Acetyl-L-carnitine as a therapeutic agent for mental deterioration in geriatric patients (Double-blind placebo controlled study). Tomassini, V., Pozzilli, C., Onesti, E., Pasqualetti, P., Marinelli, F., Pisani, A., and Fieschi, C. Comparison of the effects of acetyl L-carnitine and amantadine for the treatment of fatigue in multiple sclerosis: results of a pilot, randomised, double-blind, crossover trial. Verrina, E., Caruso, U., Calevo, M. G., Emma, F., Sorino, P., De, Palo T., Lavoratti, G., Turrini, Dertenois L., Cassanello, M., Cerone, R., and Perfumo, F. Effect of carnitine supplementation on lipid profile and anemia in children on chronic dialysis. The best part? View abstract. View abstract. carnitine 2020;27(3):e229-e234. Metabolism 2009;58(11):1618-1623. Holzhauer, P. Casuistry: medical nutrition intervention with specific micronutrient and exercise therapy in pancreatic cancer. Serban MC, Sahebkar A, Mikhailidis DP, et al. View abstract. El-Beshlawy, A., El, Accaoui R., Abd El-Sattar, M., Gamal El-Deen, M. H., Youssry, I., Shaheen, N., Hamdy, M., El-Ghamrawy, M., and Taher, A. View abstract. 10-18-2008;152(42):2298-2301. View abstract. View abstract. View abstract. 1999; Altunbasak, S., Baytok, V., Tasouji, M., Herguner, O., Burgut, R., and Kayrin, L. Asymptomatic hyperammonemia in children treated with valproic acid. Learn more about essential, Lysine is an essential amino acid that people need to obtain from their diet. View abstract. OTHER NAMES(S): 3-carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminiu, OTHER NAME(S): 3-carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminiu, L-carnitine is a chemical that is made in the human. View abstract. J Clin Rheumatol. View abstract. Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease. View abstract. Kavukcu, S., Turkmen, M., Salman, S., Onvural, B., Oktay, G., Karaman, O., and Cevik, N. T. The effects of L-carnitine on respiratory function tests in children undergoing chronic hemodialysis. Soczynska, J. K., Kennedy, S. H., Chow, C. S., Woldeyohannes, H. O., Konarski, J. Valcour, V., Yeh, T. M., Bartt, R., Clifford, D., Gerschenson, M., Evans, S. R., Cohen, B. Cureus. Clin Lymphoma Myeloma Leuk. Ardissone P, Baccolla D, Barberis L, and et al. Blood 1998;91:3817-24. Miguel-Carrasco, J. L., Mate, A., Monserrat, M. T., Arias, J. L., Aramburu, O., and Vazquez, C. M. The role of inflammatory markers in the cardioprotective effect of L-carnitine in L-NAME-induced hypertension. Obstet.Gynecol. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Jpn Circ.J 1992;56(1):86-94. Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials with dose-response analysis. Circulation 5-1-1996;93(9):1685-1689. Int J Vitam Nutr Res 1995;65:211-4. L-carnitine, also known as levocarnitine, is a naturally occurring amino acid structure that the body produces. J Pain Symptom.Manage. Calabrese, V., Giuffrida Stella, A. M., Calvani, M., and Butterfield, D. A. Acetylcarnitine and cellular stress response: roles in nutritional redox homeostasis and regulation of longevity genes. Acetyl L-carnitine, however, is more easily taken up by the intestines and the muscle cells, not to mention the brain, in the absence of food. Segura-Bruna, N., Rodriguez-Campello, A., Puente, V., and Roquer, J. Valproate-induced hyperammonemic encephalopathy. 2013 Sep;67(7):659-63. A., Kraemer, W. J., Hatfield, D. L., Vingren, J. L., Fragala, M. S., Ho, J. Y., Thomas, G. A., Hakkinen, K., and Volek, J. S. Effects of L-carnitine L-tartrate supplementation on muscle oxygenation responses to resistance exercise. WebHere are some of the most important beneficial effects associated with L-Carnitine administration: promotes fatty acid oxidation accelerates the fat-burning process stabilizes blood sugar and eliminates carb cravings increases energy levels and reduces fatigue improves skeletal muscle mass and exercise performance View abstract. View abstract. 2010;47(2):165-167. Riva R, Albani F, Gobbi G, et al. View abstract. J Med.Toxicol. J NeuroAIDS. 2009;61(4):215-217. Hamedi-Kalajahi F, Imani H, Mojtahedi S, Shabbidar S. Effect of L-Carnitine Supplementation on Inflammatory Markers and Serum Glucose in Hemodialysis Children: A Randomized, Placebo-Controlled Clinical Trial. Clin J Pain 2008;24(8):731-733. View abstract. Epilepsia 1998;39:1216-25. Weigel, C., Kiener, C., Meier, N., Schmid, P., Rauh, M., Rascher, W., and Knerr, I. Carnitine status in early-treated children, adolescents and young adults with phenylketonuria on low phenylalanine diets. Klin.Wochenschr 12-15-1988;66(24):1202-1211. View abstract. J Cardiovasc.Pharmacol 2007;50(2):168-175. Eur Heart J 1994;15:1267-73. View abstract. Obes Rev. G.Ital.Nefrol. Controlled study on L-carnitine therapeutic efficacy in post-infarction. Barker, G. A., Green, S., Askew, C. D., Green, A. Wang Y, Xu Y, Zou R, et al. 1987;24(4):231-234. 2010;44(7-8):1287-1293. View abstract. Panjwani, U., Thakur, L., Anand, J. P., Singh, S. N., Amitabh, Singh, S. B., and Banerjee, P. K. Effect of L-carnitine supplementation on endurance exercise in normobaric/normoxic and hypobaric/hypoxic conditions. View abstract. Corsi, C., Pollastri, M., Marrapodi, E., Leanza, D., Giordano, S., and D'Iddio, S. L-propionylcarnitine effect on postexercise and postischemic hyperemia in patients affected by peripheral vascular disease. Yang SK, Xiao L, Song PA, Xu X, Liu FY, Sun L. Effect of L-carnitine therapy on patients in maintenance hemodialysis: a systematic review and meta-analysis. View abstract. View abstract. This is because the injections help your body release stored triglycerides, which results in more energy. J Inherit.Metab Dis 2008;31(4):503-507. Effect of l-carnitine supplementation on children and adolescents with nonalcoholic fatty liver disease (NAFLD): a randomized, triple-blind, placebo-controlled clinical trial. View abstract. Clin Eur 1983;22:405-415. Zhonghua Nan.Ke.Xue. Andrologia 2019;51(6):e13267. Acta Diabetol. Cattaneo CI, Ressico F, Valsesia R, D'Innella P, Ballabio M, Fornaro M. Sudden valproate-induced hyperammonemia managed with L-carnitine in a medically healthy bipolar patient: Essential review of the literature and case report. View abstract. View abstract. Int J Sport Nutr Exerc.Metab 2010;20(2):104-114. L-carnitine supplements may interact with certain antibiotics or anticonvulsants. View abstract. 
Clin Auton.Res 2000;10(1):13-16. Find out more about its benefits. 1987;1(4):238-241. View abstract. Coulter DL. B., Karall, D., de, Klerk H., Knerr, I., Koch, H. G., Plecko, B., Roschinger, W., Schwab, K. O., Scheible, D., Wijburg, F. A., Zschocke, J., Mayatepek, E., and Wendel, U. View abstract. Laforet, P. and Vianey-Saban, C. Disorders of muscle lipid metabolism: diagnostic and therapeutic challenges. Donnelly, C. T., Hameed, A. A., and Greenhaff, P. L. Increasing muscle carnitine content alters muscle fuel metabolism and improves exercise performance in humans. A Meta-Analysis of the Efficacy of L-Carnitine/L-Acetyl-Carnitine or N-Acetyl-Cysteine in Men With Idiopathic Asthenozoospermia. Ther Apher Dial 2020. Diabetes Res Clin Pract 1991;14:191-5. Epilepsia 1996;37:687-9. Ann Neurol 1994;35:482-7. Raskind JY, El-Chaar GM. Nikolaos, S., George, A., Telemachos, T., Maria, S., Yannis, M., and Konstantinos, M. Effect of L-carnitine supplementation on red blood cells deformability in hemodialysis patients. Preventive effect of L-carnitine on scar formation during acute pyelonephritis: A randomized placebo-controlled trial. Am J Clin.Nutr 2009;89(1):71-76. And despite what you may have read, it's safe. J.Mazandaran Univ.Med.Sci. Famularo, G., Moretti, S., Alesse, E., Trinchieri, V., Angelucci, A., Santini, G., Cifone, G., and De, Simone C. Reduction of glutamate levels in HIV-infected subjects treated with acetylcarnitine. 2014 May;29(5):997-1004. Graziano F, Renato B, Catalano V, and et al. 2010;68(5):743-752. 2004;97(2):c41-c48. Reduction of serum carnitine concentrations during anticonvulsant therapy with phenobarbital, valproic acid, phenytoin, and carbamazepine in children. Liammongkolkul, S., Kuptanon, C., Wasant, P., Vatanavicharn, N., Sawangareetrakul, P., Keeratichamroen, S., Cairns, J. R. K., Srisomsap, C., and Svasti, J. [L-carnitine: safe and effective for asthenozoospermia]. Hemodial.Int. View abstract. WebRatiopharm L-Carnitine 10G Injection is a dietary supplement containing L-Carnitine, a naturally occurring amino acid that plays a crucial role in energy metabolism. 2010;58(5):551-565. Urology. Prev Nutr Food Sci 2020;25(2):124-32. El Beshlawy, A., Mohtar, G., Abd El, Ghafar E., Abd El Dayem, S. M., El Sayed, M. H., Aly, A. Krahenbuhl S. Carnitine metabolism in chronic liver disease. 2010;16(5):420-422. View abstract. Hiatt WR, Regensteiner JG, Creager MA, et al. Does left ventricular function improve with L-carnitine after acute myocardial infarction? 2010;30(4):233-239. Cruciani RA, Dvorkin E, Homel P, et al. Battistin L, Pizzolato G, Dam M, and et al. Oncologist. Mantovani, G., Maccio, A., Madeddu, C., Serpe, R., Massa, E., Dessi, M., Panzone, F., and Contu, P. Randomized phase III clinical trial of five different arms of treatment in 332 patients with cancer cachexia. Gramignano, G., Lusso, M. R., Madeddu, C., Massa, E., Serpe, R., Deiana, L., Lamonica, G., Dessi, M., Spiga, C., Astara, G., Maccio, A., and Mantovani, G. Efficacy of l-carnitine administration on fatigue, nutritional status, oxidative stress, and related quality of life in 12 advanced cancer patients undergoing anticancer therapy. View abstract. Acute systemic and splanchnic haemodynamic effects of L-carnitine in patients with cirrhosis. Nutr.Res. Asilsoy, S., Bekem, O., Karaman, O., Uzuner, N., and Kavukcu, S. Serum total and free carnitine levels in children with asthma. Biochem Pharmacol 1995;49:1403-10. J Pediatr Gastroenterol Nutr 1987;7:220-224. Costa, M., Canale, D., Filicori, M., D'lddio, S., and Lenzi, A. L-carnitine in idiopathic asthenozoospermia: a multicenter study. Gentile, V., Antonini, G., Antonella, Bertozzi M., Dinelli, N., Rizzo, C., Ashraf, Virmani M., and Koverech, A. View abstract. 2006;85(5):1409-1414. Roure, R., Oddos, T., Rossi, A., Vial, F., and Bertin, C. Evaluation of the efficacy of a topical cosmetic slimming product combining tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol, In vitro, ex vivo and in vivo studies. 2009;4(27):45-52. Smith, W. A., Fry, A. C., Tschume, L. C., and Bloomer, R. J. Heinonen OJ. L-Carnitine is a naturally occurring substance that the body needs for energy. Methods Mol.Biol. Giammusso B, Morgia G, Spampinato A, and et al. Effects of L- and DL-carnitine on patients with impaired exercise tolerance. Bonilla, Guerrero R., Wolfe, L. A., Payne, N., Tortorelli, S., Matern, D., Rinaldo, P., Gavrilov, D., Melan, M., He, M., Steinberg, S. J., Raymond, G. V., Vockley, J., and Gibson, K. M. Essential fatty acid profiling for routine nutritional assessment unmasks adrenoleukodystrophy in an infant with isovaleric acidaemia. Al-Sannaa, N. A. and Cheriyan, G. M. Carnitine-acylcarnitine translocase deficiency. View abstract. Xue, Y. Ann.Vasc.Surg. Pehlivanoglu S, Enar R Mutlu H Sert A Ersalni M Yazicioglu N. The effect of L-carnitine on left ventricular function in patients with acute myocardial infarction treated with streptokinase. View abstract. View abstract. View abstract. Some people may experience mild side effects when increasing their L-carnitine intake, especially with long-term use. 2014 Feb;99(2):408-22. View abstract. For one, carnitine reduces oxidative damage in the body's nitric oxide (NO). Weschler, A., Aviram, M., Levin, M., Better, O. S., and Brook, J. G. High dose of L-carnitine increases platelet aggregation and plasma triglyceride levels in uremic patients on hemodialysis. View abstract. O'Brien, D., Chunduri, P., Iyer, A., and Brown, L. L-carnitine attenuates cardiac remodelling rather than vascular remodelling in deoxycorticosterone acetate-salt hypertensive rats. N-acetyl-L-cysteine, and L-carnitine tartrate Role of acetyl-L-carnitine in the treatment of cognitive deficit in chronic alcoholism. View abstract. View abstract. The effect of preoperative L-carnitine supplementation on myocardial metabolism during aorto-coronary-bypass surgery. 2006;13(9):923-929. Watanabe, S., Ajisaka, R., Masuoka, T., Yamanouchi, T., Saitou, T., Toyama, M., Takeyasu, N., Sakamoto, K., and Sugishita, Y. Yarizadh H, Shab-Bidar S, Zamani B, Vanani AN, Baharlooi H, Djafarian K. The effect of L-carnitine supplementation on exercise-induced muscle damage: A systematic review and meta-analysis of randomized clinical trials. View abstract. Curr Med Res Opin 2004;20:1377-84. Carnitine, a quaternary ammonium compound found in almost all cells, has a critical role in transporting long-chain fatty acids across the inner mitochondrial membrane. 2010;45(6):762-763. Arenas, J., Ricoy, J. R., Encinas, A. R., Pola, P., D'Iddio, S., Zeviani, M., Didonato, S., and Corsi, M. Carnitine in muscle, serum, and urine of nonprofessional athletes: effects of physical exercise, training, and L-carnitine administration. Mate, A., Miguel-Carrasco, J. L., Monserrat, M. T., and Vazquez, C. M. Systemic antioxidant properties of L-carnitine in two different models of arterial hypertension. Am J Kidney Dis 1995;26(5):757-764. Pignatelli, P., Tellan, G., Marandola, M., Carnevale, R., Loffredo, L., Schillizzi, M., Proietti, M., Violi, F., Chirletti, P., and Delogu, G. Effect of L-carnitine on oxidative stress and platelet activation after major surgery. The kidneys also eliminate excess carnitine through urine to maintain healthful concentrations. Amen, D. G., Wu, J. C., Taylor, D., and Willeumier, K. Reversing brain damage in former NFL players: implications for traumatic brain injury and substance abuse rehabilitation. Zhonghua Nei Ke.Za Zhi. View abstract. Modern Preventive Med. Your doctor may change the dose if needed. 2009;19(73):43-50. Cruciani RA, Zhang JJ, Manola J, Cella D, Ansari B, Fisch MJ. Bellinghieri, G., Savica, V., Mallamace, A., Di, Stefano C., Consolo, F., Spagnoli, L. G., Villaschi, S., Palmieri, G., Corsi, M., and Maccari, F. Correlation between increased serum and tissue L-carnitine levels and improved muscle symptoms in hemodialyzed patients. Miwa, S. and Takikawa, O. G.Ital.Cardiol. 1992;141(11):379-384. El Beshlawy, A., Abd, El Raouf, Mostafa, F., Talaat, M., Isma'eel, H., Aoun, E., Hoffbrand, A. V., and Taher, A. Diastolic dysfunction and pulmonary hypertension in sickle cell anemia: is there a role for L-carnitine treatment? Scaglia F, Longo N. Primary and secondary alterations of neonatal carnitine metabolism. Cavallini G, Caracciolo S, Vitali G, et al. View abstract. Infusionsther.Klin Ernahr. (Pakistan) 2006;6(5):800-805. Tejani, A. M., Wasdell, M., Spiwak, R., Rowell, G., and Nathwani, S. Carnitine for fatigue in multiple sclerosis. Immunopharmacol.Immunotoxicol. L-carnitine: a way to decrease cellular toxicity of ifosfamide? Shang R, Sun Z, Li H. Effective dosing of L-carnitine in the secondary prevention of cardiovascular disease: a systematic review and meta-analysis. Amino.Acids 2012;42(5):1783-1792. Carnitine: What are the benefits and risks? View abstract. 2003;23(5):270-277. Clin Ther 1995;17:176-85. Jimenez Caballero, P. E. and Marsal, Alonso C. [Type 1 glutaric aciduria: clinical and therapeutic implications]. Endurance benefits. J Inherit.Metab Dis 2007;30(3):341-349. There are few negative side effects from this supplement at reasonable doses. Vopr.Kurortol.Fizioter.Lech.Fiz Kult. Ann Neurol 1994;36:680-1. Bachmann HU, Hoffmann A. Interaction of food supplement L-carnitine with oral anticoagulant acenocoumarol. Hauck, E. W., Diemer, T., Schmelz, H. U., and Weidner, W. A critical analysis of nonsurgical treatment of Peyronie's disease. The effects of magnesium, L-carnitine, and concurrent magnesium-L-carnitine supplementation in migraine prophylaxis. Epilepsia 1993;34:184-7. Ann.Clin Lab Sci 2009;39(4):399-404. Minerva Urol.Nefrol. View abstract. Long-term effect of acetyl-L-carnitine on myocardial 123I-MIBG uptake in patients with diabetes. BMC Cardiovasc Disord. L carnitine is a substance that the human brain, kidneys, and liver produce. 
New Trends Clin Neuropharmacol 1989;3(2):131-132. 2020;151:104554. Sirtori, C. R., Calabresi, L., Ferrara, S., Pazzucconi, F., Bondioli, A., Baldassarre, D., Birreci, A., and Koverech, A. L-carnitine reduces plasma lipoprotein(a) levels in patients with hyper Lp(a). Sabba, C., Berardi, E., Antonica, G., Ferraioli, G., Buonamico, P., Godi, L., Brevetti, G., and Albano, O. Abdel-Azid MT, Abdou MS, Soliman K, and et al. View abstract. They're all similar, and similarly effective. It can lead to muscle weakness, stunted growth, an enlarged liver, and a number of other problems. 2007;22(5):727-733. View abstract. 2001;23 Suppl 1:S85-S89. Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease. J Gerontol.A Biol.Sci Med.Sci 2008;63(10):1027-1033. Jun DW, Kim BI, Cho YK, Kim HJ, Kwon YO, Park SY, Han SY, Baek YH, Jung YJ, Kim HY, Kim W, Heo J, Woo HY, Hwang SG, Rim KS, Choi JY, Bae SH, Lee YS, Lim YS,Cheong JY, Cho SW, Lee BS, Kim SH, Sohn JH, Kim TY, Paik YH, Kim JK, Lee KS. 2010;16(10):919-921. Abd-Allah, A. R., Helal, G. K., Al-Yahya, A. World J Gastroenterol. Van Wouwe JP. View abstract. Carnitine deficiency during valproic acid treatment. View abstract. Jing, L., Li, W. M., Zhou, L. J., and Song, J. Korean J.Nutrition 2007;40(7):630-638. Other forms of carnitine include: L-carnitine, and carnitine in general, is a key component in creating energy for the cells. De Simone C, Catania S, Trinchieri V, and et al. Med.Clin (Barc.) Carnitine occurs in almost every cell in the body and in most foods. Kidney Blood Press Res. Wang, S. B., Weng, W. C., Lee, N. C., Hwu, W. L., Fan, P. C., and Lee, W. T. Mutation of mitochondrial DNA G13513A presenting with Leigh syndrome, Wolff-Parkinson-White syndrome and cardiomyopathy. Kaviani, M., Nourshahi, M., and Shokoohi, F. The effects of acute L-carnitine administration on ventilatory breakpoint and exercise performance during incremental exercise. Westend61/Adobe Stock. Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, Zara Risoldi Cochrane, Pharm.D., M.S., FASCP. View abstract. Lu, S. M., Li, X., Zhang, H. B., Hu, J. M., Yan, J. H., Liu, J. L., and Chen, Z. J. Am.J Emerg.Med. View abstract. Curr Ther Res 1985;38:256-264. View abstract. You can learn more about how we ensure our content is accurate and current by reading our. Spasov, A. Feillet, F., Ogier, H., Cheillan, D., Aquaviva, C., Labarthe, F., Baruteau, J., Chabrol, B., de, Lonlay P., Valayanopoulos, V., Garnotel, R., Dobbelaere, D., Briand, G., Jeannesson, E., Vassault, A., and Vianey-Saban, C. [Medium-chain acyl-CoA-dehydrogenase (MCAD) deficiency: French consensus for neonatal screening, diagnosis, and management]. Adefovir dipivoxil. Eur.J Neurol. 2006;17(2):73-88. Am J Clin Nutr 1989;49(2):283-289. Askarpour M, Hadi A, Miraghajani M, Symonds ME, Sheikhi A, Ghaedi E. Beneficial effects of l-carnitine supplementation for weight management in overweight and obese adults: An updated systematic review and dose-response meta-analysis of randomized controlled trials. Fertil Steril 2004;81:1578-84. View abstract. A., Iezhitsa, I. N., Kravchenko, M. S., Pisarev, V. B., and Snigur, G. L. Effects of L-, D-, and DL-carnitine on morphometric parameters of skeletal muscle and exercise performance of laboratory animals receiving carnitine-deficient diet. Effect of carni Q-gel (ubiquinol and carnitine) on cytokines in patients with heart failure in the Tishcon study. An analysis of 3 multicenter studies and a bibliographic review]. Clin Ter. Minerva Anestesiol. The safety and efficacy of adefovir dipivoxil, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults: a randomized, double-blind, placebo-controlled trial. Exp.Diabetes Res. Malaguarnera, M., Bella, R., Vacante, M., Giordano, M., Malaguarnera, G., Gargante, M. P., Motta, M., Mistretta, A., Rampello, L., and Pennisi, G. Acetyl-L-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy. 2010;20(6):711-723. Am.J Emerg.Med. Zhonghua Yi.Xue.Za Zhi. View abstract. 2009;21(7):762-770. View abstract. Increases in walking distance in patients with peripheral vascular disease treated with L-carnitine: a double-blind, cross-over study. Efficacy of L-propionylcarnitine treatment in patients with left ventricular dysfunction. View abstract. Safarinejad, M. R., Hosseini, S. Y., and Kolahi, A. View abstract. Pregnancy-related changes of carnitine and acylcarnitine concentrations of plasma and erythrocytes. View abstract. 2008;118(5):281-290. View abstract. Melegh B, Kerner J, Sandor A, et al. It may help treat a range of health conditions. A., Cotman, C. W., and Sullivan, P. G. Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging. More research is necessary, but some studies support this idea. Mar.Drugs 2009;7(1):57-70. 2012;2:CD006659. Int J Clin Pharmacol Res 1992;12:299-304. [Efficacy of natural vitamin E on oligospermia and asthenospermia: a prospective multi-centered randomized controlled study of 106 cases]. Seattle, WA: University of Washington, Seattle;1993. Pickard, R. Editorial comment on: Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. Sahebkar a, et al, V., and L-carnitine tartrate role of acetyl-L-carnitine in 's! Carnitine and acylcarnitine concentrations of plasma and erythrocytes alters muscle fuel metabolism and improves exercise performance humans... And Morrow, G. M. 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Clin Auton.Res 2000;10(1):13-16. Find out more about its benefits. 1987;1(4):238-241. View abstract. Coulter DL. B., Karall, D., de, Klerk H., Knerr, I., Koch, H. G., Plecko, B., Roschinger, W., Schwab, K. O., Scheible, D., Wijburg, F. A., Zschocke, J., Mayatepek, E., and Wendel, U. View abstract. Laforet, P. and Vianey-Saban, C. Disorders of muscle lipid metabolism: diagnostic and therapeutic challenges. Donnelly, C. T., Hameed, A. A., and Greenhaff, P. L. Increasing muscle carnitine content alters muscle fuel metabolism and improves exercise performance in humans. A Meta-Analysis of the Efficacy of L-Carnitine/L-Acetyl-Carnitine or N-Acetyl-Cysteine in Men With Idiopathic Asthenozoospermia. Ther Apher Dial 2020. Diabetes Res Clin Pract 1991;14:191-5. Epilepsia 1996;37:687-9. Ann Neurol 1994;35:482-7. Raskind JY, El-Chaar GM. Nikolaos, S., George, A., Telemachos, T., Maria, S., Yannis, M., and Konstantinos, M. Effect of L-carnitine supplementation on red blood cells deformability in hemodialysis patients. Preventive effect of L-carnitine on scar formation during acute pyelonephritis: A randomized placebo-controlled trial. Am J Clin.Nutr 2009;89(1):71-76. And despite what you may have read, it's safe. J.Mazandaran Univ.Med.Sci. Famularo, G., Moretti, S., Alesse, E., Trinchieri, V., Angelucci, A., Santini, G., Cifone, G., and De, Simone C. Reduction of glutamate levels in HIV-infected subjects treated with acetylcarnitine. 2014 May;29(5):997-1004. Graziano F, Renato B, Catalano V, and et al. 2010;68(5):743-752. 2004;97(2):c41-c48. Reduction of serum carnitine concentrations during anticonvulsant therapy with phenobarbital, valproic acid, phenytoin, and carbamazepine in children. Liammongkolkul, S., Kuptanon, C., Wasant, P., Vatanavicharn, N., Sawangareetrakul, P., Keeratichamroen, S., Cairns, J. R. K., Srisomsap, C., and Svasti, J. [L-carnitine: safe and effective for asthenozoospermia]. Hemodial.Int. View abstract. WebRatiopharm L-Carnitine 10G Injection is a dietary supplement containing L-Carnitine, a naturally occurring amino acid that plays a crucial role in energy metabolism. 2010;58(5):551-565. Urology. Prev Nutr Food Sci 2020;25(2):124-32. El Beshlawy, A., Mohtar, G., Abd El, Ghafar E., Abd El Dayem, S. M., El Sayed, M. H., Aly, A. Krahenbuhl S. Carnitine metabolism in chronic liver disease. 2010;16(5):420-422. View abstract. Hiatt WR, Regensteiner JG, Creager MA, et al. Does left ventricular function improve with L-carnitine after acute myocardial infarction? 2010;30(4):233-239. Cruciani RA, Dvorkin E, Homel P, et al. Battistin L, Pizzolato G, Dam M, and et al. Oncologist. Mantovani, G., Maccio, A., Madeddu, C., Serpe, R., Massa, E., Dessi, M., Panzone, F., and Contu, P. Randomized phase III clinical trial of five different arms of treatment in 332 patients with cancer cachexia. Gramignano, G., Lusso, M. R., Madeddu, C., Massa, E., Serpe, R., Deiana, L., Lamonica, G., Dessi, M., Spiga, C., Astara, G., Maccio, A., and Mantovani, G. Efficacy of l-carnitine administration on fatigue, nutritional status, oxidative stress, and related quality of life in 12 advanced cancer patients undergoing anticancer therapy. View abstract. Acute systemic and splanchnic haemodynamic effects of L-carnitine in patients with cirrhosis. Nutr.Res. Asilsoy, S., Bekem, O., Karaman, O., Uzuner, N., and Kavukcu, S. Serum total and free carnitine levels in children with asthma. Biochem Pharmacol 1995;49:1403-10. J Pediatr Gastroenterol Nutr 1987;7:220-224. Costa, M., Canale, D., Filicori, M., D'lddio, S., and Lenzi, A. L-carnitine in idiopathic asthenozoospermia: a multicenter study. Gentile, V., Antonini, G., Antonella, Bertozzi M., Dinelli, N., Rizzo, C., Ashraf, Virmani M., and Koverech, A. View abstract. 2006;85(5):1409-1414. Roure, R., Oddos, T., Rossi, A., Vial, F., and Bertin, C. Evaluation of the efficacy of a topical cosmetic slimming product combining tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol, In vitro, ex vivo and in vivo studies. 2009;4(27):45-52. Smith, W. A., Fry, A. C., Tschume, L. C., and Bloomer, R. J. Heinonen OJ. L-Carnitine is a naturally occurring substance that the body needs for energy. Methods Mol.Biol. Giammusso B, Morgia G, Spampinato A, and et al. Effects of L- and DL-carnitine on patients with impaired exercise tolerance. Bonilla, Guerrero R., Wolfe, L. A., Payne, N., Tortorelli, S., Matern, D., Rinaldo, P., Gavrilov, D., Melan, M., He, M., Steinberg, S. J., Raymond, G. V., Vockley, J., and Gibson, K. M. Essential fatty acid profiling for routine nutritional assessment unmasks adrenoleukodystrophy in an infant with isovaleric acidaemia. Al-Sannaa, N. A. and Cheriyan, G. M. Carnitine-acylcarnitine translocase deficiency. View abstract. Xue, Y. Ann.Vasc.Surg. Pehlivanoglu S, Enar R Mutlu H Sert A Ersalni M Yazicioglu N. The effect of L-carnitine on left ventricular function in patients with acute myocardial infarction treated with streptokinase. View abstract. View abstract. View abstract. Some people may experience mild side effects when increasing their L-carnitine intake, especially with long-term use. 2014 Feb;99(2):408-22. View abstract. For one, carnitine reduces oxidative damage in the body's nitric oxide (NO). Weschler, A., Aviram, M., Levin, M., Better, O. S., and Brook, J. G. High dose of L-carnitine increases platelet aggregation and plasma triglyceride levels in uremic patients on hemodialysis. View abstract. O'Brien, D., Chunduri, P., Iyer, A., and Brown, L. L-carnitine attenuates cardiac remodelling rather than vascular remodelling in deoxycorticosterone acetate-salt hypertensive rats. N-acetyl-L-cysteine, and L-carnitine tartrate Role of acetyl-L-carnitine in the treatment of cognitive deficit in chronic alcoholism. View abstract. View abstract. The effect of preoperative L-carnitine supplementation on myocardial metabolism during aorto-coronary-bypass surgery. 2006;13(9):923-929. Watanabe, S., Ajisaka, R., Masuoka, T., Yamanouchi, T., Saitou, T., Toyama, M., Takeyasu, N., Sakamoto, K., and Sugishita, Y. Yarizadh H, Shab-Bidar S, Zamani B, Vanani AN, Baharlooi H, Djafarian K. The effect of L-carnitine supplementation on exercise-induced muscle damage: A systematic review and meta-analysis of randomized clinical trials. View abstract. Curr Med Res Opin 2004;20:1377-84. Carnitine, a quaternary ammonium compound found in almost all cells, has a critical role in transporting long-chain fatty acids across the inner mitochondrial membrane. 2010;45(6):762-763. Arenas, J., Ricoy, J. R., Encinas, A. R., Pola, P., D'Iddio, S., Zeviani, M., Didonato, S., and Corsi, M. Carnitine in muscle, serum, and urine of nonprofessional athletes: effects of physical exercise, training, and L-carnitine administration. Mate, A., Miguel-Carrasco, J. L., Monserrat, M. T., and Vazquez, C. M. Systemic antioxidant properties of L-carnitine in two different models of arterial hypertension. Am J Kidney Dis 1995;26(5):757-764. Pignatelli, P., Tellan, G., Marandola, M., Carnevale, R., Loffredo, L., Schillizzi, M., Proietti, M., Violi, F., Chirletti, P., and Delogu, G. Effect of L-carnitine on oxidative stress and platelet activation after major surgery. The kidneys also eliminate excess carnitine through urine to maintain healthful concentrations. Amen, D. G., Wu, J. C., Taylor, D., and Willeumier, K. Reversing brain damage in former NFL players: implications for traumatic brain injury and substance abuse rehabilitation. Zhonghua Nei Ke.Za Zhi. View abstract. Modern Preventive Med. Your doctor may change the dose if needed. 2009;19(73):43-50. Cruciani RA, Zhang JJ, Manola J, Cella D, Ansari B, Fisch MJ. Bellinghieri, G., Savica, V., Mallamace, A., Di, Stefano C., Consolo, F., Spagnoli, L. G., Villaschi, S., Palmieri, G., Corsi, M., and Maccari, F. Correlation between increased serum and tissue L-carnitine levels and improved muscle symptoms in hemodialyzed patients. Miwa, S. and Takikawa, O. G.Ital.Cardiol. 1992;141(11):379-384. El Beshlawy, A., Abd, El Raouf, Mostafa, F., Talaat, M., Isma'eel, H., Aoun, E., Hoffbrand, A. V., and Taher, A. Diastolic dysfunction and pulmonary hypertension in sickle cell anemia: is there a role for L-carnitine treatment? Scaglia F, Longo N. Primary and secondary alterations of neonatal carnitine metabolism. Cavallini G, Caracciolo S, Vitali G, et al. View abstract. Infusionsther.Klin Ernahr. (Pakistan) 2006;6(5):800-805. Tejani, A. M., Wasdell, M., Spiwak, R., Rowell, G., and Nathwani, S. Carnitine for fatigue in multiple sclerosis. Immunopharmacol.Immunotoxicol. L-carnitine: a way to decrease cellular toxicity of ifosfamide? Shang R, Sun Z, Li H. Effective dosing of L-carnitine in the secondary prevention of cardiovascular disease: a systematic review and meta-analysis. Amino.Acids 2012;42(5):1783-1792. Carnitine: What are the benefits and risks? View abstract. 2003;23(5):270-277. Clin Ther 1995;17:176-85. Jimenez Caballero, P. E. and Marsal, Alonso C. [Type 1 glutaric aciduria: clinical and therapeutic implications]. Endurance benefits. J Inherit.Metab Dis 2007;30(3):341-349. There are few negative side effects from this supplement at reasonable doses. Vopr.Kurortol.Fizioter.Lech.Fiz Kult. Ann Neurol 1994;36:680-1. Bachmann HU, Hoffmann A. Interaction of food supplement L-carnitine with oral anticoagulant acenocoumarol. Hauck, E. W., Diemer, T., Schmelz, H. U., and Weidner, W. A critical analysis of nonsurgical treatment of Peyronie's disease. The effects of magnesium, L-carnitine, and concurrent magnesium-L-carnitine supplementation in migraine prophylaxis. Epilepsia 1993;34:184-7. Ann.Clin Lab Sci 2009;39(4):399-404. Minerva Urol.Nefrol. View abstract. Long-term effect of acetyl-L-carnitine on myocardial 123I-MIBG uptake in patients with diabetes. BMC Cardiovasc Disord. L carnitine is a substance that the human brain, kidneys, and liver produce. New Trends Clin Neuropharmacol 1989;3(2):131-132. 2020;151:104554. Sirtori, C. R., Calabresi, L., Ferrara, S., Pazzucconi, F., Bondioli, A., Baldassarre, D., Birreci, A., and Koverech, A. L-carnitine reduces plasma lipoprotein(a) levels in patients with hyper Lp(a). Sabba, C., Berardi, E., Antonica, G., Ferraioli, G., Buonamico, P., Godi, L., Brevetti, G., and Albano, O. Abdel-Azid MT, Abdou MS, Soliman K, and et al. View abstract. They're all similar, and similarly effective. It can lead to muscle weakness, stunted growth, an enlarged liver, and a number of other problems. 2007;22(5):727-733. View abstract. 2001;23 Suppl 1:S85-S89. Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease. J Gerontol.A Biol.Sci Med.Sci 2008;63(10):1027-1033. Jun DW, Kim BI, Cho YK, Kim HJ, Kwon YO, Park SY, Han SY, Baek YH, Jung YJ, Kim HY, Kim W, Heo J, Woo HY, Hwang SG, Rim KS, Choi JY, Bae SH, Lee YS, Lim YS,Cheong JY, Cho SW, Lee BS, Kim SH, Sohn JH, Kim TY, Paik YH, Kim JK, Lee KS. 2010;16(10):919-921. Abd-Allah, A. R., Helal, G. K., Al-Yahya, A. World J Gastroenterol. Van Wouwe JP. View abstract. Carnitine deficiency during valproic acid treatment. View abstract. Jing, L., Li, W. M., Zhou, L. J., and Song, J. Korean J.Nutrition 2007;40(7):630-638. Other forms of carnitine include: L-carnitine, and carnitine in general, is a key component in creating energy for the cells. De Simone C, Catania S, Trinchieri V, and et al. Med.Clin (Barc.) Carnitine occurs in almost every cell in the body and in most foods. Kidney Blood Press Res. Wang, S. B., Weng, W. C., Lee, N. C., Hwu, W. L., Fan, P. C., and Lee, W. T. Mutation of mitochondrial DNA G13513A presenting with Leigh syndrome, Wolff-Parkinson-White syndrome and cardiomyopathy. Kaviani, M., Nourshahi, M., and Shokoohi, F. The effects of acute L-carnitine administration on ventilatory breakpoint and exercise performance during incremental exercise. Westend61/Adobe Stock. Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, Zara Risoldi Cochrane, Pharm.D., M.S., FASCP. View abstract. Lu, S. M., Li, X., Zhang, H. B., Hu, J. M., Yan, J. H., Liu, J. L., and Chen, Z. J. Am.J Emerg.Med. View abstract. Curr Ther Res 1985;38:256-264. View abstract. You can learn more about how we ensure our content is accurate and current by reading our. Spasov, A. Feillet, F., Ogier, H., Cheillan, D., Aquaviva, C., Labarthe, F., Baruteau, J., Chabrol, B., de, Lonlay P., Valayanopoulos, V., Garnotel, R., Dobbelaere, D., Briand, G., Jeannesson, E., Vassault, A., and Vianey-Saban, C. [Medium-chain acyl-CoA-dehydrogenase (MCAD) deficiency: French consensus for neonatal screening, diagnosis, and management]. Adefovir dipivoxil. Eur.J Neurol. 2006;17(2):73-88. Am J Clin Nutr 1989;49(2):283-289. Askarpour M, Hadi A, Miraghajani M, Symonds ME, Sheikhi A, Ghaedi E. Beneficial effects of l-carnitine supplementation for weight management in overweight and obese adults: An updated systematic review and dose-response meta-analysis of randomized controlled trials. Fertil Steril 2004;81:1578-84. View abstract. A., Iezhitsa, I. N., Kravchenko, M. S., Pisarev, V. B., and Snigur, G. L. Effects of L-, D-, and DL-carnitine on morphometric parameters of skeletal muscle and exercise performance of laboratory animals receiving carnitine-deficient diet. Effect of carni Q-gel (ubiquinol and carnitine) on cytokines in patients with heart failure in the Tishcon study. An analysis of 3 multicenter studies and a bibliographic review]. Clin Ter. Minerva Anestesiol. The safety and efficacy of adefovir dipivoxil, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults: a randomized, double-blind, placebo-controlled trial. Exp.Diabetes Res. Malaguarnera, M., Bella, R., Vacante, M., Giordano, M., Malaguarnera, G., Gargante, M. P., Motta, M., Mistretta, A., Rampello, L., and Pennisi, G. Acetyl-L-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy. 2010;20(6):711-723. Am.J Emerg.Med. Zhonghua Yi.Xue.Za Zhi. View abstract. 2009;21(7):762-770. View abstract. Increases in walking distance in patients with peripheral vascular disease treated with L-carnitine: a double-blind, cross-over study. Efficacy of L-propionylcarnitine treatment in patients with left ventricular dysfunction. View abstract. Safarinejad, M. R., Hosseini, S. Y., and Kolahi, A. View abstract. Pregnancy-related changes of carnitine and acylcarnitine concentrations of plasma and erythrocytes. View abstract. 2008;118(5):281-290. View abstract. Melegh B, Kerner J, Sandor A, et al. It may help treat a range of health conditions. A., Cotman, C. W., and Sullivan, P. G. Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging. More research is necessary, but some studies support this idea. Mar.Drugs 2009;7(1):57-70. 2012;2:CD006659. Int J Clin Pharmacol Res 1992;12:299-304. [Efficacy of natural vitamin E on oligospermia and asthenospermia: a prospective multi-centered randomized controlled study of 106 cases]. Seattle, WA: University of Washington, Seattle;1993. Pickard, R. Editorial comment on: Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. Sahebkar a, et al, V., and L-carnitine tartrate role of acetyl-L-carnitine in 's! 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